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A key event in this process is diapedesis, or trans-endothelial migration, in which leukocytes exit the bloodstream and traverse the vascular and lymphatic endothelial barriers to reach sites of inflammation (209)

In August 2025, Wegovy received accelerated approval for the treatment of adults with metabolic dysfunction-associated steatohepatitis (MASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver

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doi: 10.1016/j.neuroscience.2016.09.047 187 Acaz-FonsecaEDuranJCCarreroPGarcia-SeguraLMArevaloMA

These studies have shed light on new potential therapeutic targets and biomarkers, charting fresh avenues for OA diagnosis and treatment

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