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In terms of behavioral testing, Dihexa was assessed for its ability to reverse deficits induced by the administration of scopolamine, seen in the subjects performance in the water maze test

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on cynomolgus monkeys (25 males and 25 females, aged 35 years) utilizing rotigotine behenate-loaded PLGA microspheres (rotigotine loading of 56.256.7%) as a long-acting dopamine agonist formulation for the treatment of PD through continuous dopaminergic stimulation 138

Hypoxia causes the production of ROS, which inhibit the degradation of the hypoxia-inducible factor 1 (HIF-1) (78)

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