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After being released into the bloodstream by the pituitary gland, TSH then stimulates the thyroid to release the thyroid hormones T3 and T4

Since then, glucose, glucose derivatives, multivalent glucosides, p -aminophenyl--D-mannopyranoside, mannose-derivatised liposomes, and 2-deoxy-D-glucose derivatives have been employed for glucose transporter-mediated brain targeting [18]

This suggests that precise local application might not be entirely necessary to achieve the desired outcome

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The external carotid artery was ligated near the common carotid artery