"Smaller players will likely need to demonstrate either superior tolerability, novel indication-specific efficacy, meaningfully different dosing convenience, or combination strategies that address limitations of current agents, particularly muscle loss, rather than simply competing on weight-loss magnitude alone," says Nadolsky
Nutrients, 2021.Nedeltcheva, A., Kilkus, J., Imperial, J., Schoeller, D., & Penev, P
Contraindications and Interactions Retatrutide is still in trial phases
There are currently no active UK Retatrutide trials
The active ingredient in Zepbound, along with GLP-1 agonists, appears to modulate the brains reward pathways
Effects of once-weekly subcutaneous retatrutide on weight and metabolic markers: a systematic review and meta-analysis