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Though these are a normal part of human metabolism, they cause significant oxidative stress over time, damaging DNA inside cells and leading to premature aging

That is the inflection point

Moreover, britanin, a bioactive terpenoid extracted from Inula lineariifolia , increased intracellular GPX4 and GSH levels and diminished ferroptosis-induced MIR injury via AMPK/GSK3/Nrf2 signaling [90]

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Left unchecked, these are harmful to DNA and cells, so glutathione serves to protect these, too