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[267] In another randomized study published in 2003 (Meneilly et al.), 16 elderly, insulin-nave patients with diabetes were divided in two groups of 8 patients each, and given either a continuous subcutaneous infusion of GLP-1 at an initial dose of 100 pmol/kg/h, titrated up to a maximum dose of 120 pmol/kg/h for 12 weeks, compared to controls treated with conventional therapy
4 Efforts to extend the life of native GLP-1 led to the development of human GLP-1 analogs liraglutide, albiglutide, dulaglutide, and semaglutide