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These medicines have defined indications, regulatory review and clinical trial data

Irreversible catalytic inhibitors TCP, GSK LSD1, and RN-1 form covalent adducts in the demethylation site of LSD1 and block LSD1 activity on histones and other target proteins (Figure 1A)

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Risks and Unknowns Intellectual honesty requires acknowledging what we do not know: Less studied: Clinical trials tested specific doses (0.25mg for 4 weeks, then up)