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Interestingly, the gut metabolic module aspartate degradation I, which converts L-aspartate to oxaloacetate by aspartate aminotransferase, was elevated in SAD patients and the authors hypothesized that bacterial aspartate aminotransferase enzyme activity may represent a link between gut microbiome function and the tryptophan-kynurenine pathway, a key physiological system in psychiatric disorders (Butler et al., 2023)
A once-daily oral version is also in the works for those who dislike injections
PT 141 takes a different route by stimulating neural circuits that drive desire
A simple rotation: abdomen (right), abdomen (left), right thigh, left thigh, repeat
12 , e1005817 (2016)
This surge reflects not only the medical potential of new anti-obesity drugs but also the growing recognition of obesity as a chronic, treatable disease with systemic implications for public health, healthcare expenditure, and the global economy
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