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Mutations in the p53 tumor suppressor gene: important milestones at the various steps of tumorigenesis

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98 In addition, Muc2 gene mutation in mice can induce endoplasmic reticulum stress in intestinal epithelial cells, and the misfolding of intrinsic proteins in the intestinal epithelium triggers the inflammatory response of intestinal epithelial cells, thereby destroying the structure and function of the intestinal barrier in mice and promoting the progression of UC by affecting the intestinal microbiota

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in fact, an estimated 95% is thought to be reabsorbed by the kidneys (1)