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5-Amino-1-methylquinolinium (5-Amino-1MQ) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), the cytosolic enzyme that methylates nicotinamide to 1-methylnicotinamide (1-MNA) using S-adenosyl-L-methionine (SAM) as the methyl donor
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Also, it strongly counteracts corticosteroid-induced adverse effects (i.e., eventual healing failure (Klicek et al., 2008
This results in more sustainable improvements with fewer side effects compared to traditional hormone therapies
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