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Specifically, through the formation of disulfide bonds between catalytic cysteines, H 2 O 2 inactivates phosphatase and tensin homolog phosphatase (PTEN) and unlocks the phosphoinositide 3-kinase (PI3-K)-dependent recruitment of its downstream kinases, such as protein kinase B (Akt) 16 , or oxidizes the redox protein thioredoxin and thus suppresses its inhibitory effect on the p38MAPK signaling cascade 17
GLUTATHIONE: The "Mother of ALL Antioxidants"
C., Xu, R., & Berger, N
2011;(12):CD006282
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Role of Selenium-Dependent Glutathione Peroxidases (Seleno-GPxs) in Radio-Modulation: Lessons for Radiation Oncology
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